Comparing TG Therapeutics (TGTX) & Protagonist Therapeutics (PTGX)

TG Therapeutics (NASDAQ: TGTX) and Protagonist Therapeutics (NASDAQ:PTGX) are both small-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their profitability, valuation, earnings, analyst recommendations, risk, institutional ownership and dividends.


This table compares TG Therapeutics and Protagonist Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
TG Therapeutics -73,217.77% -151.21% -116.84%
Protagonist Therapeutics N/A -64.21% -50.51%

Earnings and Valuation

This table compares TG Therapeutics and Protagonist Therapeutics’ revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
TG Therapeutics $150,000.00 6,617.55 -$78.25 million ($1.93) -7.28
Protagonist Therapeutics N/A N/A -$37.17 million ($2.78) -6.28

Protagonist Therapeutics has lower revenue, but higher earnings than TG Therapeutics. TG Therapeutics is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

Institutional and Insider Ownership

46.9% of TG Therapeutics shares are owned by institutional investors. Comparatively, 47.5% of Protagonist Therapeutics shares are owned by institutional investors. 16.7% of TG Therapeutics shares are owned by company insiders. Comparatively, 15.5% of Protagonist Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Analyst Ratings

This is a summary of current recommendations and price targets for TG Therapeutics and Protagonist Therapeutics, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
TG Therapeutics 0 0 8 0 3.00
Protagonist Therapeutics 0 0 3 0 3.00

TG Therapeutics currently has a consensus target price of $27.36, indicating a potential upside of 94.71%. Protagonist Therapeutics has a consensus target price of $37.00, indicating a potential upside of 111.91%. Given Protagonist Therapeutics’ higher probable upside, analysts clearly believe Protagonist Therapeutics is more favorable than TG Therapeutics.


Protagonist Therapeutics beats TG Therapeutics on 7 of the 11 factors compared between the two stocks.

About TG Therapeutics

TG Therapeutics, Inc. (TG) is a biopharmaceutical company focused on the acquisition, development and commercialization of treatments for B-cell malignancies and autoimmune diseases. As of December 31, 2016, the Company was developing two therapies targeting hematological malignancies. TG-1101 (ublituximab) is a glycoengineered monoclonal antibody that targets a specific epitope on the cluster of differentiation (CD20) antigen found on mature B-lymphocytes. The Company is also developing TGR-1202, an orally available Phosphoinositide 3-kinase (PI3K) delta inhibitor. Both TG-1101 and TGR-1202 are in clinical development for patients with hematologic malignancies. The Company also has pre-clinical programs focusing on developing interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors and anti- programmed cell death ligand 1 (PD-L1) and anti- glucocorticoid-induced tumor necrosis factor receptor (GITR) antibodies.

About Protagonist Therapeutics

Protagonist Therapeutics, Inc. is a clinical-stage biopharmaceutical company with a peptide technology platform focused on discovering and developing new chemical entities (NECs) to address significant unmet medical needs. The Company’s product pipeline includes PTG-100, PTG-200 and PTG-300. Its primary focus is on developing oral peptide drugs that target biological pathways also targeted by marketed injectable antibody drugs. PTG-100 is an oral, alpha-4-beta-7 (a4b7) integrin-specific antagonist peptide product candidate, which has completed a Phase I clinical trial in normal healthy volunteers (NHVs). PTG-100 is being developed for treatment of moderate-to-severe ulcerative colitis (UC). PTG-200 is an oral Interleukin-23 receptor (IL-23R) antagonist being developed for moderate-to-severe Crohn’s disease (CD). PTG-200 is in investigational new drug (IND) enabling studies. PTG-300 is an injectable hepcidin mimetic for treatment of iron overload related rare diseases.

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