Comparing Crispr Therapeutics (NASDAQ:CRSP) and Sangamo Therapeutics (NASDAQ:SGMO)

Crispr Therapeutics (NASDAQ:CRSP) and Sangamo Therapeutics (NASDAQ:SGMO) are both medical companies, but which is the superior investment? We will contrast the two businesses based on the strength of their risk, analyst recommendations, institutional ownership, valuation, dividends, earnings and profitability.

Risk and Volatility

Crispr Therapeutics has a beta of 3.11, indicating that its stock price is 211% more volatile than the S&P 500. Comparatively, Sangamo Therapeutics has a beta of 2.99, indicating that its stock price is 199% more volatile than the S&P 500.

Insider & Institutional Ownership

49.0% of Crispr Therapeutics shares are owned by institutional investors. Comparatively, 57.4% of Sangamo Therapeutics shares are owned by institutional investors. 21.4% of Crispr Therapeutics shares are owned by company insiders. Comparatively, 1.3% of Sangamo Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Profitability

This table compares Crispr Therapeutics and Sangamo Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Crispr Therapeutics -8,839.02% -50.90% -39.83%
Sangamo Therapeutics -113.03% -24.67% -15.26%

Analyst Ratings

This is a summary of recent recommendations for Crispr Therapeutics and Sangamo Therapeutics, as provided by MarketBeat.com.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Crispr Therapeutics 2 3 7 0 2.42
Sangamo Therapeutics 0 3 0 0 2.00

Crispr Therapeutics currently has a consensus price target of $49.14, suggesting a potential upside of 0.07%. Sangamo Therapeutics has a consensus price target of $13.33, suggesting a potential upside of 12.14%. Given Sangamo Therapeutics’ higher probable upside, analysts clearly believe Sangamo Therapeutics is more favorable than Crispr Therapeutics.

Valuation and Earnings

This table compares Crispr Therapeutics and Sangamo Therapeutics’ revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Crispr Therapeutics $3.12 million 832.82 -$164.98 million ($3.44) -14.28
Sangamo Therapeutics $84.45 million 16.24 -$68.33 million ($0.70) -16.99

Sangamo Therapeutics has higher revenue and earnings than Crispr Therapeutics. Sangamo Therapeutics is trading at a lower price-to-earnings ratio than Crispr Therapeutics, indicating that it is currently the more affordable of the two stocks.

Summary

Sangamo Therapeutics beats Crispr Therapeutics on 8 of the 14 factors compared between the two stocks.

Crispr Therapeutics Company Profile

CRISPR Therapeutics AG, a gene editing company, focuses on developing transformative gene-based medicines for the treatment of serious human diseases using its regularly interspaced short palindromic repeats associated protein-9 (CRISPR/Cas9) gene-editing platform in Switzerland. Its lead product candidate is CTX001, an ex vivo CRISPR gene-edited therapy for treating patients suffering from dependent beta thalassemia or severe sickle cell disease in which a patient's hematopoietic stem cells are engineered to produce high levels of fetal hemoglobin in red blood cells. The company is also developing CTX110, a donor-derived gene-edited allogeneic CAR-T therapy targeting cluster of differentiation 19 positive malignancies. In addition, it is developing allogeneic CAR-T programs targeting B-Cell maturation antigen and CD70; CTX120, a CAR-T cell product candidate for the treatment of multiple myeloma; CTX130 for the treatment of solid tumors and hematologic malignancies; programs to treat Hurler Syndrome and severe combined immunodeficiency disease, as well as glycogen storage disease Ia; and programs targeting diseases, such as Duchenne muscular dystrophy and cystic fibrosis. It has a collaboration agreements with Vertex Pharmaceuticals, Incorporated and Vertex Pharmaceuticals (Europe) Limited to develop, manufacture, commercialize, sell, and use various therapeutics; and StrideBio LLC to develop adeno-associated viral capsids. The company also has research collaboration agreements with Neon Therapeutics for developing neoantigen-based therapeutic vaccines and T cell therapies; Massachusetts General Hospital Cancer Center to develop T cell therapies for cancer; ViaCyte, Inc. for designing, developing, and commercializing gene-edited allogeneic stem cell therapies for the treatment of diabetes; and ProBioGen AG to develop novel in vivo delivery modalities for CRISPR/Cas9. CRISPR Therapeutics AG is headquartered in Zug, Switzerland.

Sangamo Therapeutics Company Profile

Sangamo Therapeutics, Inc. focuses on translating science into genomic medicines that transform patients' lives using platform technologies in genome editing, gene therapy, gene regulation, and cell therapy. The company's zinc finger proteins (ZFPs) could be engineered to make zinc finger nucleases (ZFNs), proteins that could be used to modify DNA sequences by adding or knocking out specific genes or genome editing; and ZFP transcription factors (ZFP TFs) proteins that can be used to increase or decrease gene expression or gene regulation. Its therapeutic products which are in Phase I/II clinical trial include SB-525 for the treatment of hemophilia A; SB-FIX for the treatment of hemophilia B; ST-400 for the treatment of beta-thalassemia; and SB-318 for the treatment of Mucopolysaccharidosis Type I and SB-913 for the treatment of Mucopolysaccharidosis Type II, which are lysosomal storage disorders (LSDs). The company also develops ST-920, a gene therapy for fabry disease. It has collaboration and license agreements with Kite Pharma, Inc., Pfizer Inc., Bioverativ Inc., and Shire International GmbH, as well as license partnerships with Dow AgroSciences LLC, Sigma-Aldrich Corporation, Genentech, Inc., Open Monoclonal Technology, Inc., F. Hoffmann-La Roche Ltd, and Hoffmann-La Roche Inc. The company was formerly known as Sangamo BioSciences, Inc. and changed its name to Sangamo Therapeutics, Inc. in January 2017. Sangamo Therapeutics, Inc. was founded in 1995 and is headquartered in Richmond, California.

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