SPDR S&P Biotech ETF (NYSEARCA:XBI) Short Interest Update

Posted by Casey Walker on May 1st, 2026

SPDR S&P Biotech ETF (NYSEARCA:XBI – Get Free Report) was the recipient of a significant decrease in short interest during the month of April. As of April 15th, there was short interest totaling 73,334,898 shares, a decrease of 14.2% from the March 31st total of 85,442,601 shares. Based on an average trading volume of 9,661,208 shares, the short-interest ratio is currently 7.6 days. Approximately 112.9% of the company’s stock are sold short.

Institutional Investors Weigh In On SPDR S&P Biotech ETF

Institutional investors have recently modified their holdings of the stock. Financial Life Planners purchased a new stake in shares of SPDR S&P Biotech ETF in the first quarter worth $27,000. UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC bought a new position in shares of SPDR S&P Biotech ETF during the fourth quarter valued at $27,000. Intesa Sanpaolo Wealth Management bought a new position in shares of SPDR S&P Biotech ETF during the fourth quarter valued at $30,000. SHP Wealth Management bought a new position in shares of SPDR S&P Biotech ETF during the fourth quarter valued at $31,000. Finally, Legacy Wealth Managment LLC ID bought a new position in shares of SPDR S&P Biotech ETF during the fourth quarter valued at $32,000.

SPDR S&P Biotech ETF Stock Down 0.6%

Shares of NYSEARCA XBI traded down $0.79 during trading on Friday, reaching $130.54. The company had a trading volume of 5,022,370 shares, compared to its average volume of 9,417,992. SPDR S&P Biotech ETF has a 12-month low of $75.68 and a 12-month high of $139.19. The stock has a market cap of $8.34 billion, a PE ratio of 11.47 and a beta of 0.88. The business’s 50-day moving average is $127.98 and its 200 day moving average is $122.62.

SPDR S&P Biotech ETF Company Profile

(Get Free Report)

SPDR S&P Biotech ETF (the Fund) seeks to closely match the returns and characteristics of the S&P Biotechnology Select Industry Index. The S&P Biotechnology Select Industry Index represents the biotechnology sub-industry portion of the S&P Total Markets Index. The S&P TMI tracks all the United States common stocks listed on the New York Stock Exchange, American Stock Exchange, National Association of Securities Dealers Automated Quotation (NASDAQ) National Market and NASDAQ Small Cap exchanges. The Biotech Index is a modified equal weight index.