uniQure (NASDAQ:QURE – Get Free Report) and Protagonist Therapeutics (NASDAQ:PTGX – Get Free Report) are both healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their earnings, institutional ownership, profitability, dividends, analyst recommendations, risk and valuation.
Earnings & Valuation
This table compares uniQure and Protagonist Therapeutics”s top-line revenue, earnings per share (EPS) and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| uniQure | $16.10 million | 93.84 | -$198.97 million | ($4.01) | -5.43 |
| Protagonist Therapeutics | $281.99 million | 29.54 | -$130.15 million | $1.03 | 125.00 |
Protagonist Therapeutics has higher revenue and earnings than uniQure. uniQure is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.
Insider & Institutional Ownership
78.8% of uniQure shares are owned by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are owned by institutional investors. 4.7% of uniQure shares are owned by insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.
Analyst Ratings
This is a summary of recent ratings and target prices for uniQure and Protagonist Therapeutics, as provided by MarketBeat.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| uniQure | 1 | 3 | 12 | 1 | 2.76 |
| Protagonist Therapeutics | 0 | 0 | 16 | 2 | 3.11 |
uniQure currently has a consensus price target of $53.25, indicating a potential upside of 144.49%. Protagonist Therapeutics has a consensus price target of $154.44, indicating a potential upside of 19.95%. Given uniQure’s higher possible upside, equities research analysts clearly believe uniQure is more favorable than Protagonist Therapeutics.
Profitability
This table compares uniQure and Protagonist Therapeutics’ net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| uniQure | -1,350.73% | -111.96% | -29.01% |
| Protagonist Therapeutics | 29.40% | 12.03% | 11.23% |
Volatility & Risk
uniQure has a beta of 1.06, indicating that its stock price is 6% more volatile than the S&P 500. Comparatively, Protagonist Therapeutics has a beta of 1.53, indicating that its stock price is 53% more volatile than the S&P 500.
Summary
Protagonist Therapeutics beats uniQure on 13 of the 15 factors compared between the two stocks.
About uniQure
uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases. It offers HEMGENIX that has completed Phase III HOPE-B pivotal trial for the treatment of hemophilia B. The company also develops AMT-130, a gene therapy that is in Phase I/II clinical study for the treatment of Huntington's disease. In addition, it is developing AMT-162, which is in preclinical trial for the treatment of superoxide dismutase 1- amyotrophic lateral sclerosis; AMT-260 that is in preclinical trial to treat temporal lobe epilepsy; AMT-191, which is in preclinical trial for the treatment of fabry disease; AMT-161 that is in preclinical trial to treat amyotrophic lateral sclerosis caused by mutations; AMT-240, which is in preclinical trial to for the treatment of autosomal dominant Alzheimer's disease; and AMT-210 that is in preclinical trial to treat Parkinson's disease. The company was founded in 1998 and is headquartered in Amsterdam, the Netherlands.
About Protagonist Therapeutics
Protagonist Therapeutics, Inc., a biopharmaceutical company, develops peptide-based drugs for hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing Rusfertide (PTG-300), an injectable hepcidin mimetic that completed phase 2 clinical trials for the treatment of polycythemia vera and other blood disorders; and JNJ-2113, an orally delivered investigational drug to block biological pathways that completed phase 2b clinical trials for the treatment of moderate-to-severe plaque psoriasis; and PN-943, an orally delivered, gut-restricted alpha 4 beta 7 specific integrin antagonist completed a phase 2 clinical trials in patients with moderate to severe ulcerative colitis. The company has a license and collaboration agreement with Takeda to commercialize rusfertide; and JNJ Innovative Medicines to co-develop Interleukin-23 receptor antagonist compound JNJ-2113. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.
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